Wolves' game away to Arsenal on Tuesday, December 28, has been postponed due to a number of coronavirus cases and injuries in Wolves squad.
It's the second festive postponement for Wolves after their Boxing Day game against Watford was also called off due to a high number of COVID-19 cases in the Watford camp.
Alongside the outbreak, Wolves currently have a number of players injured - including Hwang Hee-chan, Rayan Ait-Nouri and Willy Boly as well as longer-term absentees Pedro Neto, Jonny Castro Otto and Yerson Mosquera.
With this in mind, the Premier League put out a statement noting their agreement to Wolves' request to have the match called off.
"Arsenal FC's match against Wolverhampton Wanderers at the Emirates Stadium, due to be played at 12:30pm on Tuesday 28 December, has regrettably been postponed.
"The Premier League Board accepted the postponement application as Wolverhampton Wanderers does not have the required number of players available for the match (13 outfield players and one goalkeeper) as a result of a number of COVID-19 cases and injuries at the club.
"The Board was able to make its decision in advance of the fixture to give clarity to the affected clubs and their fans. We apologise for the inconvenience and disruption caused to supporters' festive plans," the statement read.
The announcement came just hours after Leeds' home clash with Aston Villa on the same day was called off.
"The League is aware that the decisions this week to postpone matches will disappoint supporters, and understands their frustrations at a special time of year when fans look forward to attending and watching football games.
"The League aims to provide as much clarity as possible, but unfortunately postponements sometimes have to be made at short notice, as safety is our priority," the statement further read.
Wolves' next scheduled match is now the trip to Old Trafford to face Manchester United on January 3, 2022.