The Super Eagles will be locking horns with The Pharaohs in Group D's mouth watering fixture of the Africa Cup of Nations at the Estadio Roumde Adjia.
Indeed much is awaited in the titanic AFCON clash that will see both giants go completely at it.
Nigeria head into Cameroon as one of the most successful nations on the continent, and with three Africa Cup of Nations titles to back up their claim, they are one to keep an eye out for and undoubtedly favourites to go all the way.
However, following their last triumph back in 2013, when they edged out a dogged Burkina Faso side 1-0 courtesy of Sunday Mba's winner, the Super Eagles endured a horrid run in the continental tournament, failing to qualify for the subsequent two editions.
In 2014, the West African nation secured third place in Group A of the qualifiers, two points behind Congo in the final qualifying spot, before finishing as runners-up in Group G back in 2017, five points adrift of group winners Egypt.
Nigeria then made up for their two-year absence in 2019, when they secured Bronze, courtesy of a 1-0 victory over Tunisia in the losers final after suffering a gruesome 2-1 defeat at the hands of eventual winners Algeria in the semi-finals.
Led by former manager and German tactician Gernot Rohr, the 2013 champions won four and drew two of their six qualification games to collect 14 points and finish seven points above runners-up Sierra Leone, who are making their first appearance since 1996.
Nigeria head into Tuesday's game unbeaten in all but one of their last six competitive games, picking up four wins and one draw to book a spot in the playoffs of the 2022 World Cup qualifiers after finishing first in Group C, two points ahead of second-placed Cape Verde.
Egypt, which will undoubtedly set the tone for their subsequent games, are without a win in any of the last six competitive meetings between the sides, dating back to a 1-0 victory in 2019.
Similar to Nigeria, the Pharaohs failed to make an appearance in each of the three subsequent editions, falling short in the qualifying round on each occasion, before suffering a 2-1 defeat at the hands of Cameroon in the 2017 final.
Egypt, who hosted the most recent edition of the tournament back in 2019, were sent packing in the round of 16 after losing 1-0 to South Africa and will head into Cameroon fresh off the back of a fourth-placed finish at the just-concluded Arab Cup.
Carlos Queiroz's men, who are making a record-extending 23rd AFCON appearance, have secured their place in the next round of the World Cup qualifiers after enjoying a sensational run in Group F, where they picked up four wins and two draws from six games.
Nigeria form (all competitions):
WWLWWD
Egypt form (all competitions):
WWDWLL
Notable absentees in the Super Eagles include Victor Osimhen, who was the nation's top scorer in the qualifiers with five goals, after the Napoli talisman tested positive for COVID-19.
As for Egypt, fresh reports have emerged of multiple COVID-19 cases with the trio of Mohamed Abogabal, Ibrahim Adel and coaching staff Essam El-Hadary testing positive for the virus.